Does PRP work for knee arthritis?
For many people with mild to moderate knee osteoarthritis, PRP injections reduce pain and improve function for several months, but results vary and guidelines disagree on its use. It works best after physical therapy and other standard care haven't helped enough, and it doesn't regrow cartilage. Most people have one to three image-guided injections.
Who is a good candidate?
- Mild to moderate knee osteoarthritis confirmed by exam and X-ray
- Pain that hasn't improved enough with physical therapy, weight management, bracing or medication
- You want to avoid or delay knee replacement, or you're not ready for surgery
PRP is less likely to help when arthritis is severe ("bone on bone") or when the knee is unstable or mechanically locking. In those cases, your physician will discuss other options, including surgery with an orthopedic surgeon.
What treatment involves
A small blood sample is drawn and spun to concentrate the platelets. The PRP is injected into the knee with ultrasound or X-ray guidance. The visit usually takes about an hour. Many people have one to three injections a few weeks apart, followed by a strengthening program with our physical therapists.
What the evidence shows
Studies of PRP for knee arthritis show improvement in pain and function for many patients over several months, but results vary and guidelines disagree. ACR and OARSI recommend against it; AAPM&R guidance supports it for selected patients after standard treatment hasn't worked. We'll tell you honestly whether you're likely to benefit.
Other options for knee arthritis
Cortisone injections for flares, hyaluronic acid injections, bone marrow concentrate, shockwave therapy, physical therapy and, when needed, knee replacement. See knee arthritis treatment.
Common questions
How many PRP injections will my knee need?
Commonly one to three, a few weeks apart. Your physician sets the number for your knee and includes it in your written price.
How soon will my knee feel better?
Change is gradual. People who respond usually notice it over several weeks, and improvement can continue for a few months.
Can PRP regrow cartilage?
No treatment reliably regrows worn cartilage. PRP aims to reduce pain and improve function, which is what most studies measure.
Is PRP for the knee covered by insurance?
Usually not. Medicare covers PRP only for chronic non-healing diabetic wounds, and most private plans don't cover it for knees. After a car accident, Michigan no-fault insurance may cover it when it's reasonably necessary.
